This is a full-time, on-site position in Lebanon, NH.
We are seeking a highly motivated and experienced Scientist to join our research team located in Lebanon, New Hampshire to develop novel siRNA/ASO therapeutics for disease areas such as chronic inflammatory and autoimmune diseases. The ideal candidate will have a Ph.D. in RNA Biochemistry, Th2 and/or IBD immunology or an equivalent scientific discipline. Proficiency with immunological cell-based assays, in particular specialized Th1/Th2 assays and M1/M2 assays is a plus. The ideal candidate is a great team player with solid bench skills, self-accountability, with high quality data generation, documentation, and presentation skills.
Successful candidates should be self-motivated, highly creative, have significant experience and mechanistic understanding of aspects of the RNA life cycle (e.g. mRNA processing, RNA degradation, mRNA translation, immunogenicity), and have a passion to develop and move research programs forward in a vibrant start-up environment.
Key Responsibilities:
- Develop and establish assays (cell culture and biochemical activity assays) to support hit-to-lead (H2L) and lead optimization
- Contribute to drug discovery programs, leading project execution with a focus on R&D outcomes
- Design and perform mechanism of action studies
- Implement cellular assays to study nucleic acid biology and the effect of nucleic acid manipulation (e.g., reporter assays, ASO or siRNA approaches and mutagenesis)
- Provide and communicate high-quality data on time and document results as requested
- Create and implement project strategies to identify high-quality development drug candidates, identify key decision points, and manage risk
- Identify and develop short-, mid-, and long-term R&D objectives alongside senior management
- Prioritize and coordinate research activities and allocate resources between internal staff and external contract research organizations (CROs)
- Proactively communicate project strategy, anticipate potential issues, and recommend appropriate resource decisions
- Communicate closely with internal and external team members across multiple disciplines to achieve project goals
Qualifications:
- Ph.D. in Biochemistry, Biophysics, Molecular Biology, mRNA delivery, Th2 and/or IBD immunology or an equivalent scientific discipline, or MS with ≥2 years’ experience in a biotech/pharma
- Knowledge of RNA therapeutics more broadly, RNA delivery, RNA/DNA design, and immunogenicity
- Strong molecular and cell biology background in discovery research
- Well-versed in RNA/DNA molecular biology methods as evidenced by publications in relevant journals or patents
- Proficiency in using a wide range of laboratory techniques including extensive experience in basic immunological techniques such as Th1/Th2 T cell assays, ELISA, flow cytometry, T/B/myeloid cell functional assays, and immune cell isolation is desired
- Animal handling
- Excellent lab practice and sterile techniques required
- High level of curiosity, willingness to problem-solve, high motivation to learn new skills, and excellent accountability and organization skills are desired
- High level of initiative in a small company environment including being a self-starter
- Excellent communication and interpersonal skills
- Experience working in dynamic, productive, cross-functional internal and external teams
- Possess outstanding organizational abilities with a collaborative, tactful, and goal-oriented working style
Lifordi Immunotherapeutics, Inc. is leading the way in leveraging the success of antibody-drug conjugates (ADCs) to develop treatments for autoimmune and inflammatory disorders. The company’s lead ADC, LFD-200, has demonstrated efficacy in multiple preclinical disease models by targeting myeloid and lymphoid cells using a highly internalized cell surface membrane protein. As experienced drug developers in immunology and inflammatory diseases,together with expertclinical advisors, a strong partnering track record, and funding from ARCH Venture Partners, 5AM Ventures, and Atlas Venture to support initial clinical data, Lifordi is committed to changing how immune and inflammatory diseases are treated. For more information, please visit www.lifordi.com.
To apply, please send your information and resume to careers@lifordi.com.
